Natubio USA

Sirtuins control aging: seven of them are found in humans and five in yeast. Essentially, they protect all organisms on the planet, including humans, from deterioration and disease. They work amongst many cellular pathways that control cell death, turn anti-aging genes on and off, help repair DNA, and regulate metabolism. SIRT 1 is one of the four longevity pathways.

 When more of these genes were put in organisms, the organisms’ lifespans extended by 5 to 20 percent. It was with this discovery that scientists began mimicking the genes using molecules. One of the molecules they used was NMN and the other, resveratrol.

 NMN is a Vitamin B3 (niacin) derivative. It occurs naturally and can be made from dietary sources such as fruits, milk, and vegetables. In the body, NMN is used to generate nicotinamide adenine dinucleotide (NAD+), a powerful and essential molecule that is found in every cell of the body. Believe it or not, if NAD+ levels in your body drop to zero, you’d be dead in about 30 seconds.

Also, and probably the most important when it comes to longevity and the fight against aging, NAD+ plays a crucial role in activating Sirtuins. As a matter of fact, without NAD+, the SIRT1 genes can’t work and perform their role of protecting our bodies from deterioration and disease.

Unfortunately, as we age, the levels of NAD+ fall. By the time we are 50 years old, for most of us, our NAD+ levels are about half of what they were when we were 20. This decrease in NAD+  interferes with SIRT1’s ability to defend our bodies and slow down the aging process.

There are many sources of NMN that can be found right at your local grocery. Just look for foods that are rich in Vitamin B3.

Possibly those with the highest risk of a vitamin B3 Niacin deficiency are those who consume mostly a diet of processed foods. Sugary foods, processed grains, white bread, white flour, wheat products and corn syrup can cause inadequate Niacin levels.

Vegetarians will enjoy several dietary sources of NMN. Mushrooms, green peas, potatoes, almonds and sunflower seeds. Fruits like peaches and grapefruit are great dietary sources of NMN as well.

These also include poultry and white meats like pork. One of the richest sources of NMN is within fresh fish which is high in Niacin like swordfish, tuna and salmon. But it's important to make sure that you're always choosing natural, organic sources.

For example, you will want to avoid farm-raised salmon. Instead, look for wild caught salmon from Alaska. It's unfortunate that much of today's food is grown with pesticides, synthetic hormones and is genetically modified so they have much less nutrient density.

It's important to avoid heavily processed foods. Sugary foods, processed grains, white bread, white flour, wheat products and corn syrup can cause inadequate Niacin levels.

More, you can also supplement NMN, Dr. David Sinclair takes 500mg daily, which is often two tablets every morning. This is a much easier process because the amount of food that you would need to eat to get this dosage would be substantial, and virtually impossible.

Studies have shown that NAD+ levels decrease with age. Studies in both mouse models and human subjects have demonstrated age-related decreases in circulating NAD+. NAD+ is involved in many cellular processes, including fatty acid oxidation, insulin secretion and lipid metabolism. Dysfunctions in these and other NAD+ dependent cellular functions are associated with frailty and pathophysiologies which become more common with advanced age.